发明名称 |
Serotonin 5-HT6 receptor knockout mouse |
摘要 |
The present invention features transgenic mice models for gene function, wherein the transgenic mice are characterized by having altered serotonin 5-HT6 receptor gene function. The transgenic mice may be either homozygous or heterozygous for a disruption in the endogenous 5-HT6 gene. Transgenic mice homozygous for a disruption in the endogenous 5-HT6 gene display a phenotype of increased anxiety behavior including diminished investigation of foreign objects and an elevation in stretched attend postures.
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申请公布号 |
US6060642(A) |
申请公布日期 |
2000.05.09 |
申请号 |
US19980132388 |
申请日期 |
1998.08.11 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
TECOTT, LAURENCE H.;BRENNAN, THOMAS J. |
分类号 |
C07K14/705;C12N15/85;(IPC1-7):C12N5/00;C12N15/12;A01K67/027;G01N33/15;C07H21/04 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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