| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new 1,3,8-triazaspiro[4.5]decanone compound useful as a painkiller, an antiflammatory agent, a diuretic, an anesthetic, a nerve- protective agent, an agent against arterial blood pressure disorder, an anxiolytic, an anorexing agent or a regulating agent for audibility. SOLUTION: This new compound is expressed by formula I [wherein, R1 and R2 are each a 1-4C alkyl or the like; A is a 1-7C alkyl, a 2-5C alkenyl or the like; R is H, a (substituted) 1-6C alkyl, a (substituted) 2-6C alkynyl, or the like; X is (substituted) phenyl, a (substituted) heterocycle or the like] and is, e.g. 3-(3-aminopropyl)-1-phenyl-8-(1-phenylcycloheptyl)-1,3,8- triazaspiro[4.5]decan-4-one. The compound of formula I is obtained, e.g. by Strecker synthesis reaction of a 1,3,8-triazaspiro[4.5]decanone of formula II with a ketone of formula III to form a compound of formula IV and then by subjecting the compound of formula IV to Grignard reaction with a reagent of the formula: AMgX' (wherein, X' is a halogen or the like).
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