发明名称 |
Mouse model with human immune system |
摘要 |
The present invention provides a non-human genetically immunodeficient mammal the peripheral blood of which contains a non-lethal percent of T-cells of human origin which is at least 20% as well as a non-human genetically immunodeficient mammal having a lethal percent of T-cells of human origin in the peripheral blood which is at least 60%. Also provided is a method of screening a substance for anti-HIV activity comprising obtaining a non-human genetically immunodeficient mammal having a lethal percent of human T-cells in the peripheral blood which is at least 60%; infecting the mammal with an amount of HIV sufficient to rescue the mammal from death from the effects of the lethal percent of human T-cells; administering the substance to the mammal; and determining if the substance kills the mammal by inhibiting the rescue of the mammal by HIV, the death of the mammal indicating a substance having anti-HIV activity.
|
申请公布号 |
US6060643(A) |
申请公布日期 |
2000.05.09 |
申请号 |
US19950511396 |
申请日期 |
1995.08.04 |
申请人 |
EMORY UNIVERSITY |
发明人 |
FLEMING, WILLIAM H.;WALLER, EDMUND K.;TURNER, CURTIS W. |
分类号 |
A01K67/027;(IPC1-7):C12N15/00;A61K35/00 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|