Genomic DNA encoding human interleukin-18 (IL-18, interferon- gamma inducing factor)

摘要

Disclosed is a genomic DNA encoding a polypeptide capable of inducing the production of interferon- gamma by immunocompetent cells. The genomic DNA efficiently expresses the polypeptide with high biological activities of such as inducing the production of interferon- gamma by immunocompetent cells, enhancing killer cells' cytotoxicity and inducing killer cells' formation, when introduced into mammalian host cells. The high biological activities of the polypeptide facilitate its uses to treat and/or prevent malignant tumors, viral diseases, bacterial infectious diseases and immune diseases without serious side effects when administered to humans.