| 摘要 |
The present invention concerns novel aminoacyloxyalkyl prodrugs of non-steroidal anti-inflammatory carboxylic acids of formula R-COO-R1-O-R2 wherein R-COO- represents the acyloxy residue of a non-steroidal anti-inflammatory carboxylic acid, R1 is a saturated or unsaturated, a straight-chain, branched or cyclic alkylene or alkylidene group of 1 to 8 carbon atoms, which can optionally be substituted, and R2 is the aminoacyl residue of a synthetic or natural amino acid, or a secondary, tertiary or quaternary aminoacyl group, as well as the nontoxic pharmaceutically acceptable acid addition salts thereof, methods for preparing the said prodrug forms, pharmaceutical compositions containing such prodrug forms, and methods for using the prodrug forms. |
