| 摘要 |
A compound represented by the following formula (I) is disclosed. This compound has potent antimicrobial activity against a wide spectrum of bacteria from Gram-positive bacteria to Grame-negative bacteria including beta -lactamase producing bacteria. In particular, it has higher antimicrobial activity against methicilline-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), and imipenem-resistant Pseudomonas aeruginosa than the existing onium salt type cephem derivatives and hence is very useful as a therapeutic agent for infectious diseases derived from various pathogenic bacteria. <CHEM> wherein X represents CH or N, R<1> represents a hydrogen atom, substituted or unsubstituted C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, or cycloalkyl; any one of R<2>, R<3>, R<4>, and R<5> represents R<6>R<7>NSO2NH-C1-6 alkyl where R<6> and R<7>, which may be the same or different, represent a hydrogen atom or C1-6 alkyl; and n is 0 or 1. |
