Quinoline sulfide derivatives

摘要

PCT No. PCT/JP97/02641 Sec. 371 Date Feb. 1, 1999 Sec. 102(e) Date Feb. 1, 1999 PCT Filed Jul. 30, 1997 PCT Pub. No. WO98/04529 PCT Pub. Date Feb. 5, 1998The present invention is directed to quinoline sulfide derivatives with antibacterial activities selectively against Hp, obtained by reacting quinoline-4(1H)-thione derivatives with halides and represented by the formula I wherein R1 represents hydrogen or halogen atom, C1-C6 alkoxy, C1-C6 alkylthio or di C1-C6 alkylamino; R2 and R3 respectively represent hydrogen atom or C1-C6 alkyl; one of R4 and R5 represents hydroxyl group and the other represents hydrogen atom or CR4R5 represents carbonyl; and m and n are integers, m being 1 or 2, n being 0 or 1.