发明名称 FUROPYRIDINE ANTIBACTERIALS
摘要 This invention provides a compound of formula (I): <IMG> or pharmaceutically acceptable salts thereof, wherein X1 and X2 are C or N, respectively; R1 and R2 are independently phenyl optionally substituted with a hydroxy group with proviso that X1 and X2 are not simultaneously C or N, when X1 is N, R1 is absent, and when X2 is N, R2 is absent; R3 is methyl or hydroxymethyl; R4 is formyl, hydroxymethyl or hydroxy C3-6 alkenyl; R5 is hydroxy, C3-6 alkenyl or hydroxy C3-6 alkenyl; or R4 and R5, together with the carbon atoms in the furopyridine ring to which they are attached, may form the following ring (to be fused with the furopyridine ring): <IMG> with the proviso that when R3 is methyl and R5 is 2-buten-2-yl, X2 is not N. These compounds and pharmaceutical compositions containing such compounds are useful for treating infectious diseases caused by bacteria.
申请公布号 CA2287736(A1) 申请公布日期 2000.05.02
申请号 CA19992287736 申请日期 1999.10.29
申请人 PFIZER INC. 发明人 YOSHIKAWA, NOBUJI;TRUESDELL, SUSAN JANE;WONG, JOHN WING;SUGIE, YUTAKA;SUGIURA, AKEMI
分类号 A61K31/4355;A61K31/436;A61K36/06;A61P31/04;C07D491/04;C07D491/048;C07D491/14;C07D491/153;C07G11/00;C12P1/02;C12P17/18;C12R1/645;(IPC1-7):C07D491/048;A61K31/435 主分类号 A61K31/4355
代理机构 代理人
主权项
地址