| 摘要 |
PCT No. PCT/EP97/02965 Sec. 371 Date Feb. 6, 1998 Sec. 102(e) Date Feb. 6, 1998 PCT Filed Jun. 3, 1997 PCT Pub. No. WO97/49689 PCT Pub. Date Dec. 31, 1997Novel and known bicyclic 4-aralkylaminopyrimidine derivatives of formula (I) wherein A is a benzene or imidazole ring; B is a benzene, tetralin, indane or 2-oxindole ring R is (C1-C4)perfluoroalkyl, phenyl, phenyl-(C1-C4)alkyl, hydroxy-(C1-C4)alkyl, (C1-C4)alkoxy-(C1-C4)alkyl, (C2-C4)acyloxy-(C1-C4)alkyl, halobenzoyloxy-(C1-C4)alkyl, carboxy, carbamoyl, (C1-C4)alkoxycarbonyl, cyano, (C1-C4)alkylcarbonyl, carboxy-(C1-C4)alkyl, carbamoyl-(C1-C4)alkyl, (C1-C4)alkoxycarbonyl-(C1-C4)alkyl, halo-(C1-C4)alkyl, amino-(C1-C4)alkyl, mono- or di-(C1-C4)alkylamino-(C1-C4)alkyl, sulfo-(C1-C4)alkyl or sulfamido-(C1-C4)alkyl; each of R1 and R2, which may be the same or different, is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, halogen or -NR5R6 in which each of R5 and R6, which may be the same or different, is H or C1-C4 alkyl; each of R3 and R4, which may the same or different, is hydrogen, C1-C4 alkyl, halogen, hydroxy, C1-C4 alkoxy, C1-C4 alkoxycarbonyl, nitro, cyano or CF3; and the pharmaceutically acceptable salts thereof, are tyrosine kinase inhibitors.
|
