发明名称 |
Stabilized external guide sequences |
摘要 |
Modified external guide sequence (EGS) molecules that mediate cleavage of specific target RNAs have been constructed. The modified molecules are external guide sequence molecules for RNAse P which are designed to specifically bind to and promote RNAse P-mediated cleavage of target RNA molecules and to have enhanced nuclease resistance. Specific regions are modified to achieve enhanced stability while maintaining RNAse P activity. Modified external guide sequence molecules suitable for use in the treatment of hepatitis B viral infections have been constructed.
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申请公布号 |
US6057153(A) |
申请公布日期 |
2000.05.02 |
申请号 |
US19970892747 |
申请日期 |
1997.07.14 |
申请人 |
YALE UNIVERSITY |
发明人 |
GEORGE, SHAJI T.;MA, MICHAEL;WERNER, MARTINA;PACE, UMBERTO;GOLDBERG, ALLAN R. |
分类号 |
A61K38/00;A61P31/12;C12N15/113;(IPC1-7):C12N15/63;C12N15/85;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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