发明名称 |
Antisense nucleic acid compounds inhibiting vascular endothelial growth factor |
摘要 |
The present invention provides an antisense nucleic acid compound inhibiting expression of vascular endothelial growth factor as well as therapeutic and diagnostic agents comprising the same as an active ingredient. A compound which nucleotide sequence is substantially complementary to a nucleotide sequence located upstream of a translation region in a gene coding for vascular endothelial growth factor and which inhibits 50% or more of the expression of vascular endothelial growth factor in cells is used as the antisense nucleic acid.
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申请公布号 |
US6057437(A) |
申请公布日期 |
2000.05.02 |
申请号 |
US19980120853 |
申请日期 |
1998.07.21 |
申请人 |
TAOGOSEI CO. LTD. |
发明人 |
KAMIYA, KINYA;MATSUDA, YOKO;UCHIDA, KIYOSHI |
分类号 |
C12N15/09;A61K31/70;A61K38/00;A61K48/00;A61P35/00;A61P43/00;C12N15/113;C12Q1/68;(IPC1-7):C07H21/04;C12N15/11;C12N15/85 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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