发明名称 |
Calpain inhibitors and their applications |
摘要 |
The present invention provides a method to enhance apoptosis in a cell by the administration of p53 in combination with a calpain inhibitor. The present invention provides a method of increasing the infectivity of a cell to a viral vector by treatment of the cell with a calpain inhibitor. The present invention further provides a method of enhancing transcription of a therapeutic transgene from the CMV promoter. The present invention also provides a method of suppressing the in vivo CTL response to viral vectors by the use of calpain inhibitors. The present invention further provides a pharmaceutical formulation of p53 and a calpain inhibitor in a pharmaceutically acceptable carrier. The present invention provides a method of ablating neoplastic cells in a mammalian organism in vivo by the co-administration of a calpain inhibitor and p53. The present invention also provides a method of ablating neoplastic cells in a population of normal cells contaminated by said neoplastic cells ex vivo by the administration of a recombinant adenovirus in combination with a calpain inhibitor to said population. |
申请公布号 |
AU1092600(A) |
申请公布日期 |
2000.05.01 |
申请号 |
AU20000010926 |
申请日期 |
1999.10.14 |
申请人 |
CANJI, INC. |
发明人 |
ISABELLA A. ATENCIO;DRAKE M. LAFACE;MURALIDHARA RAMACHANDRA;PAUL W SHABRAM |
分类号 |
A61K38/55;A61K38/57;A61K48/00 |
主分类号 |
A61K38/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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