| 摘要 |
PURPOSE: A derivative of 1,3-diamino cyclic amine substituted quinolone, naphthyridine and benzoxazine is provided to effect superior anti-bacterial property against both of gram negative and positive bacteria. CONSTITUTION: The derivative and its pharmaceutically available salt are represented by the following formula(I) (wherein R1 is hydrogen or carboxy protection group; R2 is hydrogen, halogen, nitro, cyano, substituted or non-substituted amino, lower alkyl, or lower alkoxy group; Y is independently linear, branched or cyclic alkyl substituted or not substituted by halogen element, or phenyl group substituted or not substituted by halogen element; A is independently nitrogen, carbon or C-X where X is hydrogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkyl mercapto, halogen, nitro, cyano or alkoxycarbonyl group having 3 or less carbon atoms; A and Y together form the following group where Z is carbon, nitrogen, sulfur or oxygen element; and n is ranged from 0-4).
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