| 摘要 |
The invention relates to a peptide with growth hormone release properties, which has the general formula I : A - B - C - D (- E) p, wherein p is 0 or 1, A is hydrogen or R 1 - (CH 2) q - (X) r - (CH 2) - CO -, wherein q is 0 or an integer from 1 to 5; r is 0 or 1; s is 0 or a number from 1 to 5; R 1 is hydrogen, imidazolyl, guanidino, piperazino, morpholino, piperidino or N(R 2) - R 3, wherein each of R 2 and R 3 is independently hydrogen or lower alkyl, optionally substituted with one or more hydroxyl, pyridinyl or furanyl groups and, when r is 1, X is -NH-, -CH 2 -, - CH=CH- or other B compounds are (G) t - (H) u wherein t is 0 or 1; u is 0 or 1, G and H are aminoacid residues selected from the group consisting of natural L-aminoacids or the corresponding D-isomers thereof or non-natural aminoacids, C is a D- aminoacid of the formula -NH-CH((CH 2) w- R 4 - CO -, D is a D-aminoacid, and it also relates to a pharmaceutical composition comprising about 1 90 % peptide of the general formula I or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable ingredient
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