| 摘要 |
The compound of formula I blocks the potassium channel opened by cAMP. R1 and R2 are independently H, CF3, C2F5, C3F7, alkyl with 1-6 carbons, or a substituted or unsubstituted phenyl; or R1 and R2 together are an alkylene chain with 2-10 carbon atoms. R3 is R(10)-Cn H2n-NR(11) or R(10)-CnH2n-, (wherein R(10) is H, methyl, cycloalkyl with 3-8 carbons, CF3, C2F5 or C3F7; R(11) is H or an alkyl with 1-6 carbons; and one CH2 group in CnH2n can be replaced by -O-, -CO-, -S- or other group). R4 is R(13)-CrH2r, (wherein R(13) can be H, CF3, C2F5, C3F7, a cycloalkyl with 3-8 carbon atoms or other group; and one CH2 group in CrH2r can be replaced by -O-, -CO-, -S- or other group). At least one of R5, R6, R7 and R8 is Y-CsH2s-R(18), (wherein R(18) is substituted phenyl, substituted N-containing heterocycle with 1-9 carbons or other group), thienyl, furyl or an N-containing heterocycle with 1-9 carbons. The remaining substituents of R5, R6, R7 and R8 are independently H, F, Cl, Br, I, alkyl with 1-5 carbon atoms, cycloalkyl with 3-8 carbons, CN, NO2, OR(12e) or NR(12e)R(12f), (wherein R(12e) and R(12f) are independently H or an alkyl with 1-4 carbons). R9 is H, OR(12g) or OCOR(12g), wherein R(12g) is H or alkyl having 1-3 carbons. B is hydrogen, or together with R9 is a bond. The compound or a physiologically tolerable salt thereof is used in a medicament for therapy of cardiovascular disorders, the treatment of ulcers of the gastrointestinal area or the treatment of diarrheal disorders.
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