发明名称 |
METHODS OF HYDRATING MUCOSAL SURFACES |
摘要 |
A method of hydrating nasal airway surfaces in a subject in need of such treatment comprises topically applying a sodium channel blocker to a nasal airway surface of the subject in an amount effective to inhibit the reabsorption of water by the surface. The channel blocker may be a pyrazinolylguanidine sodium channel blocker, such as benzamil, phenamil, amiloride, or pharmaceutically acceptable salts thereof. The method may further comprise the step of topically applying a P2Y2 receptor agonist to a nasal airway surface of the subject in an amount effective to stimulate chloride secretion by the nasal airway surface. In a preferred embodiment, the sodium channel blocker is a covalent conjugate of a pyrazinoylguanidine sodium channel blocker and a non-absorbable carrier moiety (e.g., albumin, polyethylene glycol). Such compounds may also be administered to other mucosal surfaces where it is desired to inhibit the reabsorption of water.
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申请公布号 |
WO0023023(A1) |
申请公布日期 |
2000.04.27 |
申请号 |
WO1999US24546 |
申请日期 |
1999.10.20 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
BOUCHER, RICHARD, C., JR. |
分类号 |
A61K47/10;A61K9/00;A61K31/00;A61K31/4965;A61K45/00;A61K45/08;A61K47/26;A61K47/32;A61K47/34;A61K47/36;A61K47/42;A61K47/48;A61P11/02;(IPC1-7):A61F13/00 |
主分类号 |
A61K47/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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