发明名称 |
DERIVATIVES OF ERYTHROMYCIN, CLARITHROMYCIN, ROXITHROMYCIN OR AZITHROMYCIN WITH ANTIBIOTIC AND MUCOLYTIC ACTIVITY |
摘要 |
A pharmaceutical with an enhanced pharmaceutical profile comprises a mucolytic and an antibiotic in which the mucolytic is present in an amount of greater than one molar equivalent of the antibiotic. The antibiotic may be selected from Erythromycin, Roxithromycin, Clarithromycin, Azithromycin, Dirithromycin; and pharmaceutically acceptable salts or esters thereof. The mucolytic is a mucolytically active thiol, especially N-acetylcysteine, mercaptoethanesulfonic acid, tiopronin or methylcysteine. The adducts can be isolated via a simple and efficient process.
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申请公布号 |
WO0023081(A1) |
申请公布日期 |
2000.04.27 |
申请号 |
WO1999IE00106 |
申请日期 |
1999.10.15 |
申请人 |
LAUTERAL LIMITED;SCHICKANEDER, HELMUT;NIKOLOPOULOS, AGGELOS;HERMANN, GESINE |
发明人 |
SCHICKANEDER, HELMUT;NIKOLOPOULOS, AGGELOS;HERMANN, GESINE |
分类号 |
A61K31/7048;A61K31/7052;C07H17/08;(IPC1-7):A61K31/70;A61K31/195 |
主分类号 |
A61K31/7048 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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