PREPARATION OF AMINO ALCOHOLS

摘要

Process for the preparation of an amino alcohol, in which a corresponding alpha -hydroxy keto compound is brought into contact with a dehydrogenase with the aid of a cofactor in the presence of a compound that contains an -NH group. The hydroxy keto compound is preferably converted in the presence of a micro-organism or parts of it belonging in particular to one of the following genera are used: Candida, Zygoascus, Pseudomonas, Burkholderia, Comomonas, Vibrio, Enterobacter, Yersinia, Klebsiella, and Citrobacter, and especially: Pseudomonas fluorescens, Pseudomonas luteola, Pseudomonas putida, Pseudomonas species, Burkholderia cepacia, Comomonas testosteroni, Vibrio fluvialis, Vibrio species, Enterobacter cloacae, Enterobacter agglomerans, Yersinia species, Klebsiella species, Citrobacter fruendii, Zygoascus hellenicus, Candida species, with special preference for Candida sp. MUCL 41424 and more particularly deriving from Candida sp. MUCL 41424. The hydroxy keto compound is preferably prepared from the corresponding olefinically unsaturated compound, and the cofactor is regenerated.