发明名称 |
TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS BY DOWN-REGULATING THE AUTOIMMUNE RESPONSE TO AUTOANTIGENS |
摘要 |
Systemic lupus erythematosus (SLE) can be prevented or treated by down-regulating the autoimmune response to the C-terminal DNA-binding domain of the p53 protein (p53) by an active principle selected from the group consisting of: (i) a peptide of, or comprising, the C-terminal DNA-binding domain of the p53 protein; (ii) a monoclonal antibody (mAb) specific for said domain of p53 (Ab1), and fragments thereof; (iii) an mAb specific for Ab1 (hereinafter Ab2), and fragments thereof; (iv) a peptide based on a complementarity determining region (CDR) of the heavy or light chain of said Ab1 or Ab2; (v) a DNA molecule coding for (i) or (iv) or for the variable region of said Ab1 and Ab2 of (ii) and (iii); and (vi) T cells specific for (i) to (iv), fragments thereof, T cell receptor (TCR) thereof and peptides comprising the variable region of said TCR. SLE can also be diagnosed by assaying for antibodies (Ab1) against the C-terminal DNA-binding domain of p53 or antibodies (Ab2) specific to the Ab1 antibodies.
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申请公布号 |
WO0023082(A1) |
申请公布日期 |
2000.04.27 |
申请号 |
WO1999US24443 |
申请日期 |
1999.10.19 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD.;COHEN, IRUN, R.;ROTTER, VARDA;EREZ-ALON, NETA;HERKEL, JOHANNES |
发明人 |
COHEN, IRUN, R.;ROTTER, VARDA;EREZ-ALON, NETA;HERKEL, JOHANNES |
分类号 |
A61K38/11;A61K38/12;A61K39/00;C07K14/47;C07K16/18;C07K16/42;C12N5/08;G01N33/564;(IPC1-7):A61K31/70;A61K38/00;A61K39/395;G01N33/53;G01N33/558 |
主分类号 |
A61K38/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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