PROMOTION OF SELF-RENEWAL AND IMPROVED GENE TRANSDUCTION OF HEMATOPOIETIC STEM CELLS BY HISTONE DEACETYLASE INHIBITORS

摘要

A method of promoting stem cell self-renewal is disclosed which comprises exposing a population of stem cells, particularly hematopoietic stem cells, to an effective dose of a histone deacetylase inhibitor, particularly trichostatin A, trapoxin, or chlamydocin. The invention is also directed to the use of histone deacetylase inhibitors to increase the number of transduced stem cells.