| 摘要 |
A stable, aqueous insulin formulation suitable for pulmonary delivery is disclosed. The formulation comprises human insulin or an analogue thereof, 2 to 5 Zn<2+> ions per six molecules of insulin, 3 to 18 phenolic molecules per six molecules of insulin, and menthol. The characteristic smell of menthol masks the presence of phenols in the formulation without affecting the chemical and physical stability of the formulation.
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