| 发明名称 |
INTERFERON-BETA FUSION PROTEINS AND USES |
| 摘要 |
A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptide other than glycosylated interferon-beta. It is preferred that X is human interferon-beta-1a. Mutants of interferon-beta-1a are also described.
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| 申请公布号 |
CA2343094(A1) |
申请公布日期 |
2000.04.27 |
| 申请号 |
CA19992343094 |
申请日期 |
1999.10.15 |
| 申请人 |
BIOGEN, INC. |
发明人 |
RUNKEL, LAURA;WHITTY, ADRIAN;HOCHMAN, PAULA;BRICKELMAIER, MARGOT |
| 分类号 |
C12N15/09;A61K38/00;A61K38/21;A61P9/00;A61P31/12;C07K14/565;C07K17/08;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/62;C12P21/02;(IPC1-7):C12N15/62;C12P21/00;C12N15/22 |
主分类号 |
C12N15/09 |
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