| 摘要 |
Purification and crystallization of riboflavin to give more soluble form suitable for pharmaceutical or foodstuff use, by activated carbon treatment in acid solution, cross-flow filtration and precipitation. Purification and crystallization of riboflavin (I) involves: (i) dissolving acicular (I) of stable modification A in aqueous mineral acid with thorough mixing at 30 degrees C or less; (ii) adding activated carbon; (iii) removing the carbon (plus adsorbed impurities) by cross-flow filtration via a ceramic membrane of pore size 20-200 nm; (iv) treating the filtrate with a 5-10 fold volume of water at 30 degrees C or less; and (v) recovering the precipitated spherical crystals of (I) by centrifugation or filtration. |
