Tgf-beta superfamily mutant members, including morphogenic proteins

摘要

The invention provides modified proteins and DNAs of the TGF-beta superfamily including modified morphogenic proteins. The proteins of the present invention display altered biological or biochemical attributes. Specifically, the modified proteins are designed through manipulation or exchange of subdomains among two or more members of the superfamily such that certain desired attributes are mixed-and-matched and then exploited therapeutically.