发明名称 |
Increasing blood-brain barrier permeability with permeabilizer peptide derivatives of bradykinin |
摘要 |
Peptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood/brain barrier to molecules such as therapeutic agents or diagnostic agents. The permeabilizer A-7 or conformational analogues can be intravenously coadministered to a host together with molecules whose desired destination is the interstitial fluid compartment of the brain. Alternatively, the permeabilizer A-7 or conformational analogues can be administered sequentially with the molecule(s) of interest and these molecules can also be administered by routes other than intravascular. The permeabilizer A-7 or conformational analogues allow these molecules to penetrate the blood-brain barrier and arrive in the interstitial fluid. |
申请公布号 |
EP0885900(A3) |
申请公布日期 |
2000.04.26 |
申请号 |
EP19980113628 |
申请日期 |
1992.04.23 |
申请人 |
ALKERMES, INC. |
发明人 |
KOZARICH, JOHN W.;MUSSO, GARY F.;MALFROY-CAMINE, BERNARD |
分类号 |
A61K38/00;A61K38/04;A61K38/08;A61K47/42;A61K49/00;C07K7/02;C07K7/06;C07K7/18 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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