发明名称 |
Organometallic ligands for the localization and quantification of amyloid in vivo and in vitro |
摘要 |
Novel organometallic compounds for binding amyloid are described. Methods using such compounds for determining by imaging the localization or quantification of amyloid fibrils in a mammal, for diagnosing the degree of progression of Alzheimer's disease in a mammal, for monitoring the response to a therapy in a mammal having Alzheimer's disease, for identifying an agent useful for treating Alzheimer's disease, for treating Alzheimer's disease, and for detecting the presence of the infectious form of the prion protein, are also described.
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申请公布号 |
US6054114(A) |
申请公布日期 |
2000.04.25 |
申请号 |
US19970852825 |
申请日期 |
1997.05.07 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
LANSBURY, JR., PETER T.;HAN, HOGYU;CHO, CHEON-GYU;ZHEN, WEIGUO;HARPER, JAMES D.;DAVISON, ALAN |
分类号 |
A61K49/06;A61K51/04;C07B59/00;C07F13/00;(IPC1-7):A61K51/00;A61K49/00 |
主分类号 |
A61K49/06 |
代理机构 |
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