发明名称 |
Methods and compositions for stimulating tissue growth and epithelial moisturization |
摘要 |
The invention herein encompasses methods effective to stimulate epithelial cell proliferation and/or enhance epithelial moisturization and lubrication in a mammalian subject utilizing a composition comprising one or more inhibitors of beta -glucosidase activity or beta -glucocerebrosidase activity. The composition of the method may alternatively comprise a glycosphingolipid, particularly glucocerebroside, or a combination of the above inhibitor(s) and a glycosphingolipid. The method is effective to enhance the cosmetic appearance of skin and promote healing of skin and mucous membranes damaged or deficient from aging, traumatic wounds, photo-aging and a variety of atrophic conditions. The method may be applied to cells in culture. Also included in the invention is a composition comprising one or more inhibitors of beta -glucosidase and a glycosphingolipid useful to stimulate cell proliferation and enhance tissue moisturization and lubrication.
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申请公布号 |
US6054433(A) |
申请公布日期 |
2000.04.25 |
申请号 |
US19940333852 |
申请日期 |
1994.11.03 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
ELIAS, PETER MICHAEL;HOLLERAN, WALTER MARTIN |
分类号 |
A61K31/00;A61K31/047;A61K31/336;A61K31/366;A61K31/437;A61K31/445;(IPC1-7):A61K31/70;A61K31/045;A61K31/44 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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