发明名称 NOVEL TREATMENT METHOD OF LEPTIN RESISTANCE
摘要 PURPOSE: Provided is a method of treatment and(or) prevention of symptom relating to leptin resistance and complication thereof. Effective and non-toxic pharmaceutically acceptable amount of a leptin sensitization agent or pharmaceutically acceptable derivatives thereof is medicated internally. CONSTITUTION: A leptin sensitization agent is co-medicated with leptin and/or derivatives, for example, agonist. The leptin sensitization agent is an insulin sensitization agent containing thiazolidindion and acyclic insulin sensitization agent, or PPAR gamma agonist. PPAR gamma agonist contains thiazolidindion which is thiazolin-2,4-dion derivative having residue of formula A.
申请公布号 KR20000023719(A) 申请公布日期 2000.04.25
申请号 KR19997000179 申请日期 1999.01.11
申请人 SMITHKLINE BEECHAM PLC. 发明人 POST GEORGE HENRY;SMITH STEVEN ALISTARE
分类号 C07D277/20;A61K31/00;A61K31/425;A61K31/426;A61K31/427;A61K31/4439;A61K45/00;A61P3/04;A61P3/06;A61P3/10;A61P5/50;A61P9/00;C07D277/34;C07D417/06;C07D417/12;(IPC1-7):A61K31/425 主分类号 C07D277/20
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