Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
摘要
Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.
申请公布号
US6054127(A)
申请公布日期
2000.04.25
申请号
US19970884497
申请日期
1997.06.27
申请人
IMMULOGIC PHARMACEUTICAL CORPORATION
发明人
SWAIN, PHILIP A.;SCHAD, VICTORIA C.;GREENSTEIN, JULIA L.;EXLEY, MARK A.;FOX, BARBARA S.;POWERS, STEPHEN P.;GEFTER, MALCOLM L.;BRINER, THOMAS J.