发明名称 Proline derivatives
摘要 The present invention relates to particular forms of a novel 1-substituted-N-[2-methyl-1-(trifluoroacetyl)propyl]pyrrolidine-2-carboxamide which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes pharmaceutical compositions containing such forms, processes for preparing the forms and intermediates useful in the synthesis of the forms.
申请公布号 US6054593(A) 申请公布日期 2000.04.25
申请号 US19980100735 申请日期 1998.06.19
申请人 ZENECA LIMITED 发明人 VEALE, CHRIS ALLAN;BERNSTEIN, PETER ROBERT;DAVIES, ELWYN PETER
分类号 A61K38/55;A61K38/00;A61K38/06;A61P9/10;A61P11/00;A61P11/10;A61P29/00;C07C213/02;C07C215/08;C07K1/02;C07K1/14;C07K5/06;C07K5/062;C07K5/083;(IPC1-7):C07D207/16 主分类号 A61K38/55
代理机构 代理人
主权项
地址