RECOMBINANT VACCINE FOR DISEASES CAUSED BY ENCAPSULATED ORGANISMS

摘要

PURPOSE: Recombinant vaccines for diseases caused by encapsulated organisms are provided. CONSTITUTION: Vaccines for diseases caused by normally encapsulated organisms are produced by genetically modifying those organisms by deleting the genes encoding for capsule synthesis or a portion thereof sufficient to produce non capsulated mutants of the organisms. As an example, a live, attenuated strain of Actinobacillus pleuropneumoniae genetically modified with a large deletion in chromosomal regions of the DNA which encodes for capsule synthesis is a safe and effective vaccine against swine pleuropneumonia.