摘要 |
PURPOSE: Novel amidino derivatives are provided which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants. CONSTITUTION: Amino derivatives which exhibit competitive inhibitory activity towards thrombin are useful as anticoagulants and in the treatment or prophylaxis of thrombosis and hypercoagulability in blood and tissues of animals including man. The compounds are orally bio available and selective in inhibiting thrombin over other serine proteases. The method for treatment or prophylaxis consists in administration of a therapeutically effective amount of the compounds or a pharmaceutically acceptable salt thereof, to a person suffering from, or susceptible to such a condition.
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