发明名称 |
Preparation of 2-substituted pyridines |
摘要 |
This invention relates to a process for preparing 2-substituted pyridines via metal halogen exchange with sec-butyllithium on optionally substituted 2-bromo or 2-iodopyridines. The resulting lithopyridine intermediate is reacted with an electrophile to provide the desired 2-substituted pyridine. The substitution of sec-butyllithium for n-butyllithium in such a process results in an enhanced yield and purity of the desired 2-substituted pyridine.
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申请公布号 |
US6054583(A) |
申请公布日期 |
2000.04.25 |
申请号 |
US19990305410 |
申请日期 |
1999.05.05 |
申请人 |
ROHM AND HAAS COMPANY |
发明人 |
KELLY, MARTHA JEAN;WEAVER, DAMIAN GERARD |
分类号 |
C07D213/16;C07D213/24;C07D213/50;C07D213/61;C07D213/63;C07D213/70;C07D213/78;(IPC1-7):C07F7/22;C07F7/10;C07D213/71 |
主分类号 |
C07D213/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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