METHOD OF SYNTHESIS OF 2-SUBSTITUTED BENZO[B]THIOPHENE (VARIANTS), METHOD OF SYNTHESIS OF DERIVATIVES OF 2-PHENYL-3-AROYLBENZO[B]THIOPHENE (VARIANTS) AND DERIVATIVES OF BENZO[B]THIOPHENE

摘要

FIELD: organic chemistry, pharmacy, chemical technology. SUBSTANCE: invention describes the method of synthesis of the novel 2-substituted benzo[b] thiophene of the general formula (I) where values R1 and R2 are given in p. 1 of the invention claim. Method involves the synthesis of boronic acid derivative followed by its coupling with the compound of the formula X-C6H4-R2 where X means bromine or iodine atoms and R2 means H, OH or OR4 where R4 means hydroxy-protective group. Synthesized compound can be used as an intermediate substance for synthesis of pharmaceutically active compounds being others are useful for treatment of women with osteoporosis in the phase of postmenopause. EFFECT: simplified and decreased cost of process. 32 cl, 1 dwg, 3 ex