发明名称 ESTERS OF (+)-ALPHA-( 2,3- DIMETHOXYPHENYL) -1-[2-(4- FLUOROPHENYL) ETHYL]-4- PIPERIDINEMETHANOL AND THEIR USE AS PRODRUGS OF THE 5HT2A RECEPTOR ANTAGONIST MDL 110,907
摘要 <p>The present invention is directed to esters of (+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol, of formula (I) wherein R is C4-C20alkyl, pharmaceutical formulations, methods of making and methods of using these esters. These compounds antagonize the effects of serotonin at the 5HT2A receptor and are useful in treating various conditions such as, for example, psychoses such as schizophrenia.</p>
申请公布号 WO2000021930(A1) 申请公布日期 2000.04.20
申请号 US1998021608 申请日期 1998.10.14
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