发明名称 BENZOPYRANS HAVING POTASSIUM CHANNEL OPENING ACTIVITY
摘要 <p>A compound of formula (I) where the indicated OH group in the 3- position is in the trans position with respect to R?3, and R1 and R2¿ are independently hydrogen or C¿1? to C5 alkyl, R?3¿ is a group of the formula: -N(R6)-COR7 where R6 is hydrogen or C¿1? to C5 alkyl and R?7¿ is a C¿6? to C10 monovalent aromatic group or a monovalent heteroaromatic group having a 5- or 6-membered heteroaromatic ring, or R?6 and R7¿ together are 1,3-butadienylene or denote a group of formula -(CH¿2?)m- or formula (II) in which m is an integer of from 3 to 5 and n is 1 or 2, and R?4 and R5¿ are, independently, C¿1? to C5 alkyl; or a N-oxide thereof; or a physiologically-hydrolysable and -acceptable ester of a compound of formula (I) or N-oxide thereof; or a physiologically acceptable acid addition or quaternary ammonium salt of a compound of formula (I), or of an ester or N-oxide thereof.</p>
申请公布号 WO2000021957(A1) 申请公布日期 2000.04.20
申请号 EP1999007539 申请日期 1999.10.07
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