| 摘要 |
The present invention is directed to recombinant adenoviral vectors capable of replication under particular host cell conditions. In particular, the presen t invention provides adenoviruses containing modifications to the E1a region which have therapeutic and diagnostic applications. The vectors of the prese nt invention are capable of replication and lysis of neoplastic cells. The vectors may optionally include modifications to the genome so as to impart specific replicative or targeting functions. The present invention also provides pharmaceutical formulations of such vectors. The present invention further provides methods of use of such vectors. The present invention furth er provides methods of preparing the vectors.
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