发明名称 |
NOVEL CELL SIGNALING POLYPEPTIDES AND NUCLEIC ACIDS |
摘要 |
The present invention relates to an isolated SRK polypeptide, biologically-active polypeptide fragments thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction pathways, including, e.g., a protein kinase activity; an autophosphorylating activity; a cell survival promoting activity; a HAX-1 binding activity; an apoptosis suppression activity; a MAPKK stimulatory activity; a transcription modulatory activity, and a SRK-specific immunogenic activity. The invention relates to all aspects of SRK, or homologs thereof, including assays for modulators, activators, ligands, etc. The invention also relates to a cytolic or soluble HAX-1 which produces apoptosis when expressed in cells.
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申请公布号 |
WO0022142(A2) |
申请公布日期 |
2000.04.20 |
申请号 |
WO1999US22008 |
申请日期 |
1999.09.20 |
申请人 |
ONYX PHARMACEUTICALS, INC. |
发明人 |
RUGGIERI, ROSAMARIA;CALLOW, MARINELLA;DIAZ, PAUL |
分类号 |
C12N15/09;A61K31/711;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P19/02;A61P21/00;A61P25/00;A61P29/00;A61P35/00;A61P37/00;A61P43/00;C07K14/47;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/12;C12N15/54;C12Q1/02;C12Q1/48;C12Q1/68;(IPC1-7):C12N15/54;C12N15/12;C12N15/85;G01N33/68;C07K19/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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