BENZOPYRANS HAVING POTASSIUM CHANNEL OPENING ACTIVITY

摘要

A compound of formula (I) where the indicated OH group in the 3- position is in the trans position with respect to R<3>, and R<1> and R<2> are independently hydrogen or C1 to C5 alkyl, R<3> is a group of the formula: -N(R<6>)-COR<7> where R<6> is hydrogen or C1 to C5 alkyl and R<7> is a C6 to C10 monovalent aromatic group or a monovalent heteroaromatic group having a 5- or 6-membered heteroaromatic ring, or R<6> and R<7> together are 1,3-butadienylene or denote a group of formula -(CH2)m- or formula (II) in which m is an integer of from 3 to 5 and n is 1 or 2, and R<4> and R<5> are, independently, C1 to C5 alkyl; or a N-oxide thereof; or a physiologically-hydrolysable and -acceptable ester of a compound of formula (I) or N-oxide thereof; or a physiologically acceptable acid addition or quaternary ammonium salt of a compound of formula (I), or of an ester or N-oxide thereof.