NOVEL THERAPEUTIC AGENTS THAT MODULATE NEUROKININ RECEPTORS

摘要

Novel multi-binding compounds (agents) which bind neurokinin receptors are used to treat disorders in mammals that are mediated by the neurokinin receptors, such as Parkinson's disease, Alzheimer's disease, depression, anxiety, inflammation, rheumatoid arthritis, cystitis, osteoarthritis, irritable bowel syndrome, allergic rhinitis, pain, chronic pain, migraine headaches, asthma, bronchitis and chemotherapy induced emesis. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological processes/functions thereof. Each of the ligands is covalently attached to a linker or linkers which may be the same or different to provide for the multi-binding compound. The linker is selected such that the multi-binding compound so constructed demonstrates increased modulation of the biological processes mediated by the neurokinin receptor. The invention is also directed to pharmaceutical compositions comprising the multi-binding compounds, methods of inhibiting and treating the disorders mediated by neurokinin receptors, and methods of preparing multi-binding compounds of the invention.