发明名称 |
A MODIFIED POLYPEPTIDE WITH REDUCED IMMUNE RESPONSE |
摘要 |
The present invention relates to polypeptides with reduced immune response including reduced allergenicity having one or more amino acid residues being substituted with other amino acid residues and/or having coupled one or more polymeric molecules in the vicinity of the polypeptides metal binding site, a method for preparing modified polypeptides of the invention, the use of said polypeptide for reducing the immunogenicity and allergenicity and compositions comprising said polypeptide.
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申请公布号 |
WO0022103(A1) |
申请公布日期 |
2000.04.20 |
申请号 |
WO1999DK00542 |
申请日期 |
1999.10.12 |
申请人 |
NOVO NORDISK A/S |
发明人 |
OLSEN, ARNE, AGERLIN;VON DER OSTEN, CLAUS;ANDERSEN, KIM, VILBOUR;ERNST, STEFFEN;ROGGEN, ERWIN, LUDO |
分类号 |
A23L1/305;A23L1/015;A61K38/43;A61K47/48;A61P37/06;A61P37/08;C11D3/37;C11D3/38;C12N9/30;C12N9/56;C12N9/96;(IPC1-7):C12N9/96 |
主分类号 |
A23L1/305 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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