| 发明名称 |
MUTANT INTERLEUKIN 6 WITH IMPROVED BIOLOGICAL ACTIVITY OVER WILD INTERLEUKIN 6 |
| 摘要 |
<p>The present invention is drawn to mutant interleukin 6, which has the amino acid arginine in position 176, replacing serine in position 176 with wild-type interleukin 6. The mutant interleukin 6 of the present invention has greater biological activity than the wild-type protein. The present invention is further drawn to methods of making mutant interleukin 6, having arginine at position 176 and methods of using the same.</p> |
| 申请公布号 |
EP0667872(B1) |
申请公布日期 |
2000.04.19 |
| 申请号 |
EP19940900984 |
申请日期 |
1993.11.02 |
| 申请人 |
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. |
发明人 |
CILIBERTO, GENNARO;SAVINO, ROCCO |
| 分类号 |
C12N15/09;A61K38/00;C07K14/52;C07K14/54;C12N1/21;C12N15/00;C12N15/24;C12P21/02;C12R1/19;C12R1/91;(IPC1-7):C07K14/54;A61K38/20 |
主分类号 |
C12N15/09 |
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