| 发明名称 |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
| 摘要 |
T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.
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| 申请公布号 |
US6051227(A) |
申请公布日期 |
2000.04.18 |
| 申请号 |
US19960760288 |
申请日期 |
1996.12.04 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, OFFICE OF TECHNOLOGY TRANSFER |
发明人 |
ALLISON, JAMES PATRICK;LEACH, DANA R.;KRUMMEL, MATTHEW F. |
| 分类号 |
C12N15/02;A61K31/00;A61K38/00;A61K38/17;A61K38/19;A61K38/20;A61K39/00;A61K39/085;A61K39/39;A61K39/395;A61K45/00;A61K45/06;A61N5/10;A61P13/00;A61P13/12;A61P31/00;A61P31/12;A61P35/00;A61P37/00;A61P37/04;A61P43/00;C07K14/31;C07K14/705;C07K14/725;C07K16/28;C12N15/09;C12P21/08;(IPC1-7):A61K39/395 |
主分类号 |
C12N15/02 |
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