发明名称 |
DNA encoding MCK-10, a novel receptor tyrosine kinase |
摘要 |
The present invention relates to the novel family of receptor tyrosine kinases, herein referred to as MCK-10, to nucleotide sequences and expression vectors encoding MCK-10, and to methods of inhibiting MCK-10 activity. The invention relates to differentially spliced isoforms of MCK-10 and to other members of the MCK-10 receptor tyrosine kinase family. Genetically engineered host cells that express MCK-10 may be used to evaluate and screen drugs involved in MCK-10 activation and regulation. The invention relates to the use of such drugs, in the treatment of disorders, including cancer, by modulating the activity of MCK-10. |
申请公布号 |
US6051397(A) |
申请公布日期 |
2000.04.18 |
申请号 |
US19930153397 |
申请日期 |
1993.11.16 |
申请人 |
MAX PLANCK GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN |
发明人 |
ULLRICH, AXEL;ALVES, FRAUKE HILDEGARD ELISABETH |
分类号 |
A61K38/00;C07K14/705;C12N15/12;(IPC1-7):C12N5/10;C12N15/62 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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