Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings

摘要

A process for preparing a compound of the formula I: or pharmaceutical acceptable salts thereof wherein X is -NR,-, -S(O)g-, or -O-; R1 is -H, C1-6 alkyl optionally substituted with one or more -OH, -CN, or halo, or R1 is -(CH2)h-aryl, -COR1-1, 13 COOR1-2, -CO-(CH2)h-COR1-1, C1-6 alkyl sulfonyl, -SO2-(CH2)h-aryl, or -(CO)i-Het; R2 is -H, C1-6 alkyl, -(CH2)h-aryl, or halo; R3 and R4 are the same or different and are -H or halo; R5 is -H, C1-12 alkyl optionally substituted with one or more halo, C3-12 cycloalkyl, C1-6 alkoxy. The compounds are useful antimicrobial agents.