Methods of treating neurodegenerative disorders using protease inhibitors

摘要

Methods of use of compounds for the treatment of disorders characterized by the cerebral deposition of amyloid are provided. Among the compounds provided for use in the methods are those of the formula: in which R1 is preferably 2-methylpropenyl, 2-butenyl, cyclohexyl or cyclohexylmethyl; R2, R4, and R8 are each preferably independently methyl or ethyl; R3 is preferably iso-butyl or phenyl; R5 is preferably iso-butyl; R6 is preferably H or methyl; R7-(Q)n is preferably benzyloxycarbonyl or acetyl; Q is preferably -C(O)-; and X is preferably an aldehyde, alpha -ketoester or alpha -ketoamide.