发明名称 |
Mammaglobin, a secreted mammary-specific breast cancer protein |
摘要 |
<p>A purified and isolated DNA sequence and the encoded mammary-specific secreted protein, mammaglobin, are disclosed. Also disclosed are methods for detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin. Immunotherapy-based methods for treating a breast cancer patient with a mammaglobin-expressing tumor are also disclosed. The methods involve using mammaglobin antigens to induce a humoral and/or cell-mediated immune response against the tumor.</p> |
申请公布号 |
AU6275899(A) |
申请公布日期 |
2000.04.17 |
申请号 |
AU19990062758 |
申请日期 |
1999.09.29 |
申请人 |
WASHINGTON UNIVERSITY |
发明人 |
MARK A. WATSON;TIMOTHY P. FLEMING |
分类号 |
G01N33/53;A61K38/00;A61K39/00;C07H21/02;C07H21/04;C07K14/47;C12N15/09;C12Q1/68;G01N33/566;G01N33/574;G01N33/577 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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