发明名称 |
T CELLS MEDIATING AN IMMUNE RESPONSE AND METHODS OF USE |
摘要 |
The present invention is directed to T cells, compositions, and methods of obtaining and using the same, including and not limited to methods of treating cancer. The methods of the present invention include inter alia: a method of generating T cells capable of infiltrating a tumor of a human and participating in an immune response against the tumor; and a method of treating cancer comprising administering to a human afflicted with a tumor a therapeutically effective amount of T cells that mediate tumor regression, the T cells having been either isolated from the tumor of the human after immunization of the human with a composition comprising hapten-modified tumor cells and/or expanded in vitro from T cells thus isolated.
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申请公布号 |
WO0020564(A1) |
申请公布日期 |
2000.04.13 |
申请号 |
WO1998US20888 |
申请日期 |
1998.10.02 |
申请人 |
THOMAS JEFFERSON UNIVERSITY;INSTITUTO NAZIONALE PER LO STUDIO DEI TUMORI;BERD, DAVID;PARMIANI, GIORGIO;ANICHINI, ANDREA;SENSI, MARIALUISA |
发明人 |
BERD, DAVID;PARMIANI, GIORGIO;ANICHINI, ANDREA;SENSI, MARIALUISA |
分类号 |
A61K39/00;C12N5/08;G01N33/50;G01N33/68;(IPC1-7):C12N5/08;A01N1/02;A01N63/00;A61K31/00;C12N5/00;C12N5/02 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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地址 |
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