USE OF SOCS-2 OR CIS TO SCREEN FOR COMPOUNDS ENHANCING GROWTH HORMONE EFFECT

摘要

The invention relates to the use of SOCS-2 and/or CIS, purified or recombinant, to screen for compounds enhancing the effect of growth hormone; assay systems and methods to screen for compounds that reduce the level of SOCS-2 and/or CIS comprising cultured cells in which levels of SOCS-2 and/or CIS can be monitored; to screen for compounds that reduce the biological activity of SOCS-2 and/or CIS comprising purified or recombinant SOCS-2 and/or CIS and proteins that link SOCS-2 and/or CIS to signaling molecules dependent on GH; a method to increase cellular sensitivity to GH by a reduction of the levels of SOCS-2 and/or CIS.