METHOD FOR REMOVING N-TERMINAL METHIONINE

摘要

A process for freeing a peptide having an optionally oxidized diketomethioni ne residue at the N-terminal or a salt thereof from the diketomethionine residu e, characterized by reacting the peptide or salt with 3,4-diaminobenzoic acid o r a salt thereof in the presence of acetic acid and sodium formate, formic aci d and sodium formate, or formic acid and sodium acetate; and a process for preparing peptides free from N-terminal methionine residues or salts thereof .